Roles of microRNA in the regulation of tumor-associated macrophage polarization during the remodeling of breast cancer immune microenvironment
10.3760/cma.j.cn371439-20200401-00050
- VernacularTitle:微小RNA调控肿瘤相关巨噬细胞极化在重塑乳腺癌免疫微环境中的作用
- Author:
Jiamin ZHOU
1
;
Lisha YE
;
Guohua WANG
Author Information
1. 南通大学特种医学研究院 226001
- From:
Journal of International Oncology
2020;47(7):428-430
- CountryChina
- Language:Chinese
-
Abstract:
Tumor associated macrophage (TAM), as the main type of immune cells in tumor microenvironment, becomes an active participant in the development of breast cancer. MicroRNA (miRNA) can regulate post-transcriptional gene expression, modulation of macrophage function by affecting its polarization typing and transformation, and ultimately contribute to the occurrence and development of breast cancer. It could provide a new diagnosis and clinical treatment strategy for the treatment of breast cancer by summarizing the mechanisms of miRNA in the polarization of TAM.
