Application of circulating tumor DNA in targeted therapy and immunotherapy of metastatic melanoma
10.3760/cma.j.cn371439-20191223-00041
- VernacularTitle:循环肿瘤DNA在转移性黑色素瘤靶向治疗及免疫治疗中的应用
- Author:
Mingli DU
1
;
Guixiang LI
;
Wenjuan WU
;
Lei ZHAO
Author Information
1. 兰州大学第二医院肿瘤中心伽马刀治疗科 730030
- From:
Journal of International Oncology
2020;47(6):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Targeted therapy and immunotherapy are important methods for the treatment of metastatic melanoma, but monitoring the patient′s disease progress and treatment response during the treatment is the key to accurate treatment and personalized treatment.Circulating tumor DNA (ctDNA) as a non-invasive " liquid biopsy" method, due to its high sensitivity and specificity for gene mutations, and the advantages of being qualitative, quantitative and traceable, which has shown great application value in monitoring metastatic melanoma progression, evaluating efficacy, and predicting prognosis during targeted therapy and immuno-therapy.
