Mechanisms of ferroptosis and its significance in breast cancer therapy
10.3760/cma.j.cn371439-20191206-00039
- VernacularTitle:细胞铁死亡调控机制及其在乳腺癌治疗中的意义
- Author:
Yiyue XU
1
;
Shaorong ZHAO
;
Jingjing LIU
;
Jin ZHANG
Author Information
1. 天津医科大学肿瘤医院乳腺肿瘤三科 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室 天津市恶性肿瘤临床医学研究中心 300060
- From:
Journal of International Oncology
2020;47(6):372-376
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is a malignant tumor originating from breast epithelial tissue. Ferroptosis is a novel type of programmed cell death which differs from apoptosis and necrosis. Research found that the accumulation of lipid peroxides in cells, a crucial process of ferroptosis, can be induced by multiple mechanisms. The ferroptosis regulation is closely related to the occurrence and development of breast cancer, and it induced by drugs is a potential and valuable research direction in breast cancer.
