Role of transmembrane proteins in malignant tumors
10.3760/cma.j.cn371439-20191227-00035
- VernacularTitle:跨膜蛋白在恶性肿瘤中的作用
- Author:
Qiuju MIAO
1
;
Xiulian XU
Author Information
1. 中国医学科学院皮肤病医院病理科，南京 210042
- From:
Journal of International Oncology
2020;47(6):355-359
- CountryChina
- Language:Chinese
-
Abstract:
Transmembrane proteins (TMEMs) are a class of membrane proteins, also known as integral membrane proteins, that contain at least one transmembrane structure. A variety of membrane protein function has been found closely related to the proliferation, invasion and metastasis of malignant tumors: TMEM48, TMEM45A/B, TMEM14A, TMEM158 and TMEM206 have tumor promoting effects; TMEM25 and TMEM7 have antitumor effects; TMEM16A, TMEM17, TMEM97, TMEM88 and TMEM176 play heterogeneity roles in different tumors. These TMEMs can be used as potential prognostic indicators and new therapeutic targets.
