CRYAB and tumors
10.3760/cma.j.cn371439-20200311-00034
- VernacularTitle:CRYAB与肿瘤
- Author:
Ang DAI
1
;
Qing SUN
Author Information
1. 潍坊医学院基础医学院 261053
- From:
Journal of International Oncology
2020;47(6):351-354
- CountryChina
- Language:Chinese
-
Abstract:
AlphaB-crystallin (CRYAB) plays the role of molecular chaperone, it can maintain vascular endothelial growth factor levels and promote tumor neovascularization. Several recent studies indicate that CRYAB is abnormally expressed in various tumors such as breast cancer, lung cancer, colorectal cancer, and bladder cancer. It promotes tumor migration and invasion by promoting the resistance of tumor cells to apoptosis, regulating the secretion of matrix metalloproteinase and cadherin, and participating in the epithelial-mesenchymal transition process. The abnormal expression of CRYAB in tumor cells is significantly related to tumor stage, lymph node metastasis, overall survival and poor prognosis, and can be used as a new tumor marker.
