High mobility group protein B1 and breast cancer
10.3760/cma.j.cn371439-20200414-00022
- VernacularTitle:高迁移率族蛋白B1与乳腺癌
- Author:
Yanqiang ZHANG
1
;
Yang ZHANG
;
Chunhua LI
;
Dianping ZHANG
;
Baoguo LIU
;
Xiangeng PENG
Author Information
1. 山东省聊城市人民医院乳腺甲状腺外科，山东第一医科大学(山东省医学科学院) 252000
- From:
Journal of International Oncology
2020;47(5):297-300
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group protein B1 (HMGB1) is a kind of nuclear protein widely existing in cells, which is released or secreted from cells by stress in the body and plays a key role in the survival or death pathways of cells. HMGB1 has a huge biological function and is the main regulator of major diseases such as inflammatory diseases and tumors. HMGB1 is closely related to the proliferation, differentiation, migration, apoptosis and drug resistance of tumor cells. With the continuous deepening of research on HMGB1, it is found that HMGB1 plays an important role in the occurrence, development, metastasis and drug resistance of breast cancer. Combined with the research status of HMGB1, the expression of HMGB1 in breast cancer is discussed to provide a new therapeutic scheme for clinical treatment.
