Research progress of Bub1 in cancers
10.3760/cma.j.cn371439-20200113-00020
- VernacularTitle:Bub1及其在肿瘤中的研究进展
- Author:
Mengni WANG
1
;
Weiguo LYU
Author Information
1. 浙江大学医学院附属妇产科医院肿瘤科，杭州 310006
- From:
Journal of International Oncology
2020;47(5):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Bub1 is essential for assembling of the functional spindle assembly checkpoint (SAC) to guarantee the correct separation of sister chromatids. Abnormal expression of Bub1 can elevate defects in SAC function, chromosome instability, and the incidence of aneuploidy. Several recent studies indicate that aberrantly expressed Bub1 may promote the tumorigenesis via regulating cell proliferation, invasion, migration and cancer stem cell activation. Further understanding of the mechanism of Bub1 in malignancy may provide new targeted therapy strategies.
