The role of inflammatory cytokines in chemoresistance of epithelial ovarian cancer
10.3760/cma.j.cn371439-20191010-00012
- VernacularTitle:炎症细胞因子在卵巢上皮癌化疗耐药中的作用
- Author:
Yiting YANG
1
;
Zhongping CHENG
Author Information
1. 南京医科大学上海第十人民医院临床医学院，上海 200072
- From:
Journal of International Oncology
2020;47(4):249-251
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer is a common fatal malignant tumor in women. The most common pathological type is epithelial ovarian cancer (EOC) originating from the ovary or fallopian tube epithelium, accounting for 85%-90%. The standard treatment for EOC is tumor cytoreductive surgery. Postoperative platinum/paclitaxel chemotherapy, cell chemoresistance has become an important cause of recurrence and death in EOC patients. At present, many scholars believe that the tumor environment of ovarian cancer is rich in a broad spectrum of tumor pro-inflammatory cytokines and chemokines. Inflammation can increase the division and differentiation of epithelial cells. The long-term exposure of normal epithelial tissues to the inflammatory environment will gradually turn to malignant transformation. The inflammatory tumor microenvironment promotes the invasion and metastasis of transformed malignant tumor cells, and eventually develops drug resistance.
