Zinc finger proteins and digestive system cancers
10.3760/cma.j.issn.1673-422X.2020.02.011
- VernacularTitle:锌指蛋白与消化系统肿瘤
- Author:
Chunfang TIAN
1
;
Dan SHA
Author Information
1. 山东第一医科大学附属省立医院化疗科，济南 250021
- From:
Journal of International Oncology
2020;47(2):115-118
- CountryChina
- Language:Chinese
-
Abstract:
Zinc finger proteins (ZNFs) belong to the largest transcriptional factor family in human genome. ZNFs are widely involved in the development and progression of digestive system cancers by promoting or inhibiting carcinogenesis. Studies have shown that the abnormal expressions of various ZNFs are closely related to the clinicopathologic features and prognosis of patients with digestive system cancers, including gastric cancer, liver cancer, colorectal cancer and pancreatic cancer. Exploring the underlying mechanism of ZNFs will help to provide new targets for clinical treatment of digestive system cancers.
