Research progress of oxidative stress and acute pancreatitis
10.3760/cma.j.cn115396-20191231-00247
- VernacularTitle:氧化应激与急性胰腺炎的研究进展
- Author:
Wangjun ZHANG
1
;
Bei SUN
;
Gang WANG
Author Information
1. 哈尔滨医科大学附属第一医院胰胆外科 150001
- From:
International Journal of Surgery
2020;47(9):644-648
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis (AP) is a common clinical acute abdominal disease, usually with local complications such as pancreatic necrosis, pseudocysts, and abdominal abscesses, as well as systemic inflammatory response syndrome and multiple organ dysfunction syndrome. It is dangerous, difficult to treat, and the prognosis is poor. Although significant progress has been made on the pathogenesis of AP, its specific mechanism is still unclear. In the past few decades, many studies have emphasized the role of oxidative stress in acute inflammatory response. This article clarified the role of oxidative stress in the occurrence and development of AP by introducing oxidative stress to break the cellular Ca 2+ balance, participate in the stimulation of transcription factor activation and excessive release of inflammatory mediators and introduces the application of antioxidant adjuvant therapy in the treatment of AP.
