Expression of Vimentin in metastatic renal cell carcinoma and its relationship with prognosis
10.3760/cma.j.cn115396-20190809-00136
- VernacularTitle:Vimentin在转移性肾癌中的表达及预后意义
- Author:
Xiaoyi WEI
1
;
Jiaxi YAO
;
Yujie QIN
;
Changjun YANG
;
Faying YANG
;
Xiaoyi HU
Author Information
1. 河西学院附属张掖人民医院泌尿外科 734000
- From:
International Journal of Surgery
2020;47(9):589-593,f3
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the expression of Vimentin and its relationship with clinical pathological data and prognosis in patients with metastatic renal cell carcinoma (mRCC).Methods:A total of 269 mRCC patients, from June 2007 to June 2017, treated with tyrosine kinase inhibitors (TKI) in Zhongshan Hospital, Fudan University were included in the study. Vimentin was assessed by immunohistochemistry on continuous paraffin embedded slides. To analyzed the relationship between Vimentin expression and clinicopathological data and prognosis. Measurement data were expressed as mean±standard deviation ( Mean± SD). The relationship between Vimentin expression and clinicopathological data of mRCC patients was determined by Chi-square test. Survival analysis used Kaplan-Meier survival curve, Log-rank test to judge the relationship between Vimentin expression and patient′s overall survival, and COX regression analysis was used for univariate and multivariate analysis. Results:Vimentin was expressed in cytoplasm of tumor cells. Vimentin expression in mRCC patients′ tissues was positively correlated with tumor Fuhrman grade ( P=0.002), and negatively correlated with prognostic overall survival ( P=0.001). Multivariate regression analysis showed that Vimentin expression was an independent risk factor for overall survival in patients with mRCC ( P=0.006). Conclusions:Vimentin expression can be used as a prognostic indicator of mRCC. It is expected that Vimentin can provide prediction for the prognosis of mRCC patients treated with TKI.
