Research progress in clinical predictors of pathological complete response in locally advanced rectal cancer after neoadjuvant radiochemotherapy
10.3760/cma.j.cn.115396-20191217-00236
- VernacularTitle:局部进展期直肠癌新辅助放化疗后病理完全缓解临床预测因素的研究进展
- Author:
Yalun LI
1
;
Yi XU
;
Wei GUO
;
Shu YAN
;
Xiaomu ZHAO
;
Jin WANG
Author Information
1. 首都医科大学附属北京友谊医院普外科 国家消化系统疾病临床医学研究中心，北京 100050
- From:
International Journal of Surgery
2020;47(8):563-566
- CountryChina
- Language:Chinese
-
Abstract:
Neoadjuvant chemoradiotherapy (nCRT)+ total mesorectal excision (TME) has become the standard mode of treatment for locally advanced rectal cancer(LARC). However, the sensitivity of different patients to nCRT varies greatly, some patients can get pathological complete response (pCR), and their long-term survival is significantly improved, Some patients'tumors continue to progress, therefore, accurate prediction of whether pCR can be achieved after nCRT is very important for guiding individualized treatment of patients. Current studies have shown that some accessible clinical factors, such as age, pathological types of tumors, TNM staging, circumferential extent of tumor, distance to the anal verge, CEA level, neutrophil lymphocyte ratio, can be used to predict whether pCR can be achieved.This article reviews the progress of clinical predictors of pCR in LARC after nCRT.
