Application and prospect of growth factors in clinical transplantation of tissue engineering trachea
10.3760/cma.j.cn115396-20200326-00082
- VernacularTitle:生长因子在组织工程气管临床移植中的应用与展望
- Author:
Fei SUN
1
;
Zhihao WANG
;
Hongcan SHI
Author Information
1. 扬州大学临床医学院胸外科 225001
- From:
International Journal of Surgery
2020;47(7):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Tissue engineering provides an effective treatment for tracheal reconstruction. The key to maintain airway function and ensure long-term survival of tracheal grafts is how to achieve epithelial cell regeneration, chondrocyte regeneration, and angiogenesis of the transplanted trachea. Growth factors are signaling molecules that direct cell development by providing biochemical cues for stem cell proliferation, migration, and differentiation. They play an important role in tissue engineering trachea regeneration. It is particularly important to design a delivery system that provides optimal activity, stability and adjustability for growth factors. This article summarizes the types, characteristics, functions of growth factors applied in the field of tissue engineering trachea, and the value of growth factors in tissue engineering trachea orthotopic transplantation aimed for promoting clinical transformation of tissue engineered trachea.
