Research status of immune tolerance after liver transplantation
10.3760/cma.j.cn115396-20200321-00075
- VernacularTitle:肝移植术后免疫耐受机制及诱导方法的研究现状
- Author:
Fangfei WANG
1
;
Shaocheng LYU
;
Qiang HE
Author Information
1. 首都医科大学附属北京朝阳医院肝胆外科 100020
- From:
International Journal of Surgery
2020;47(6):391-396
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation has been developed for nearly 60 years, and the operation technology has been improved day by day. However, the rejection is still one of the key factors that restrict the long-term survival of the graft and patients. Immune tolerance refers to the state of specific immune non response or low response after the immune system contacts the antigen, which is the most ideal state after organ transplantation, and the liver, as an immune immunity organ, is also the most easy to induce immune tolerance state. At present, a large number of experimental studies have confirmed that immune tolerance is related to a variety of cellular and molecular mechanisms after liver transplantation, but the realization of clinical transformation remains to be further studied. In this paper, the current research status of immune tolerance after liver transplantation was reviewed to explain its possible mechanism and induction methods.
