Glucose metabolism reprogramming during epithelial-mesenchymal transition in breast cancer
10.3760/cma.j.cn115396-20190916-00167
- VernacularTitle:乳腺癌上皮-间质转化过程中的糖代谢重编程
- Author:
Xiangnan XU
1
;
Deyuan FU
Author Information
1. 大连医科大学 116044
- From:
International Journal of Surgery
2020;47(5):350-356
- CountryChina
- Language:Chinese
-
Abstract:
Invasion and metastasis are the leading causes of death from breast cancer. Epithelial-mesenchymal transition (EMT) can induce cancer metastasis by promoting tumor malignances and reprogramming tumor metabolism. As an important part of glucose metabolism, aerobic glycolysis not only provides sufficient energy for rapid growth of tumor cells, but also provides metastasis advantage for tumor cells by promoting the EMT process. In addition, the crosstalk network between glycolysis and EMT synergistically triggers cancer metastasis. Therefore, abnormal glucose metabolism and EMT play a key role in the occurrence and development of breast cancer metastasis, suggesting its clinical promise for the management of breast cancer metastasis.
