Research progress on protective effect of liver ischemia-reperfusion injury after liver transplantation
10.3760/cma.j.issn.1673-4203.2020.03.014
- VernacularTitle:肝移植术后肝缺血再灌注损伤保护作用的研究进展
- Author:
Hao LONG
1
;
Yajun CHEN
;
Jianping GONG
Author Information
1. 重庆市大足区人民医院肝胆外科 402360
- From:
International Journal of Surgery
2020;47(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury is the most common complication after liver transplantation. Oxidative stress, autophagy, and inflammatory response caused by excessive reactive oxygen species production are significant steps that cause liver ischemia-reperfusion injury. What′s more, nuclear factor erythroid 2-related factor 2 is considered to be a major regulator of the antioxidant response, the PI3K-Akt-mTOR signaling pathway is considered to be an important pathway of autophagy, and the HMGB1-TLR4-NF-κB signaling pathway is considered to be a key signaling pathway which leads to inflammation. Based on the above signaling pathways and regulatory factor, this article shows that the antioxidant, anti-inflammatory and autophagy regulation effects of genes, molecules and drugs on hepatic ischemia-reperfusion cells, to explore the protective effects on hepatic ischemia-reperfusion cells.
