Research progress of miRNA in ovarian cancer
10.3760/cma.j.cn121382-20200508-00512
- VernacularTitle:miRNA在卵巢癌中的研究进展
- Author:
Wei LI
1
;
Qing SHANG
;
Weiping ZHANG
;
Jing MA
Author Information
1. 天津中医药大学第一附属医院检验科 300193
- From:
International Journal of Biomedical Engineering
2020;43(5):406-411
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer is one of the most common gynecological malignancies leading to female deaths, and its early diagnosis and prevention are very complicated. Therefore, biomarkers for this disease prediction and prognosis are urgently needed for early diagnosis and individualized treatment. miRNAs are short-chain, highly conserved non-coding RNA molecules that mainly degrade or inhibit target genes at the post-transcriptional level to regulate cell growth, proliferation, differentiation, metabolism, and apoptosis. Existing studies have confirmed that miRNAs can be used as potential biomarkers for clinical diagnosis and treatment of cancer. Moreover, tumor-related miRNAs play an important role in the occurrence, invasion and metastasis of ovarian cancer by regulating the expression of multiple oncogenes and tumor suppressor genes. In this paper, the roles of miRNAs as biomarkers for early prevention or detection of ovarian cancer, prognostic diagnosis and treatment targets were reviewed, and the future clinical application of miRNA in patients with ovarian cancer was proposed.
