Research progress in mechanical barrier function of intestinal mucosa in nonalcoholic fatty liver disease
10.3760/cma.j.cn121382-20200502-00510
- VernacularTitle:非酒精性脂肪性肝病肠道黏膜机械屏障功能的研究进展
- Author:
Wei ZHANG
1
;
Hua'nan LI
;
Xiongfei LUO
;
Siwen LIU
;
Na ZHAO
;
An BAO
;
Yingying CHEN
;
Jingui WANG
Author Information
1. 天津中医药大学第一附属医院推拿科 300193
- From:
International Journal of Biomedical Engineering
2020;43(5):394-399,411
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal mucosal barrier is the first line of defense against exogenous substances. A complete mechanical barrier can separate the body from the contents of the intestines and prevent the translocation of bacteria and microorganisms in the intestines, playing an important role in maintaining the homeostasis of the human body. If the intestinal mechanical barrier function is damaged, it will cause the intestinal endotoxin and bacterial translocation, leading to systemic inflammatory response syndrome and multiple organ dysfunction diseases. The barrier function of intestinal mucosa is a key link in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Therefore, the maintenance of intestinal mucosal barrier function is of great value for the diagnosis and treatment of NAFLD. In this paper, the research progress in intestinal mechanical barrier function of NAFLD was reviewed, and the main factors maintaining intestinal permeability of NAFLD were introduced, such as apoptosis, autophagy, apical junctional complex, cytoskeleton, main signal pathway, to provide reference for the diagnosis and treatment of NAFLD.
