Research progress of mesenchymal stem cells in peripheral nerve injury repair
10.3760/cma.j.cn121382-20200530-00508
- VernacularTitle:间充质干细胞在周围神经损伤修复中的研究进展
- Author:
Dedong LI
1
;
Jian SUN
;
Mingdong YU
;
Bo LI
;
Yuechun LU
Author Information
1. 天津医科大学第二医院麻醉科 300211
- From:
International Journal of Biomedical Engineering
2020;43(5):382-386
- CountryChina
- Language:Chinese
-
Abstract:
Peripheral nerve injury (PNI) is an important clinical complication, which brings long-term physical and psychological pain and economic burden to patients. There is no satisfactory treatment plan for PNI. Although microsurgery technology has been greatly developed, some peripheral nerve defects or ruptures caused by external forces can be repaired by surgery or nerve transplantation. However, due to the weak ability of nerve cell regeneration and surgical operations may cause damage to the injured nerves, the patient's functional recovery may not be able to achieve the desired effect. Therefore, it is urgent to find a safe and effective method to treat PNI. Mesenchymal stem cells have special differentiation potential and can differentiate into a variety of cell types in vitro and in vivo, and have received widespread attention from researchers. In this paper, the research progress of mesenchymal stem cells in nerve injury repair was summarized, and the characteristics, functions of mesenchymal stem cells and the mechanism of action in peripheral nerve injury repair were reviewed.
