ERLIN2 expression in glioblastoma and its correlation with prognosis
10.3760/cma.j.issn.1673-4181.2020.01.006
- VernacularTitle:胶质母细胞瘤中ERLIN2的表达情况及其与预后的相关性
- Author:
Zebin LIU
1
;
Zhengzheng XIAO
;
Zheng SHAO
;
Bo FAN
Author Information
1. 河南科技大学临床医学院，河南科技大学第一附属医院神经外科，洛阳 471003
- From:
International Journal of Biomedical Engineering
2020;43(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression of endoplasmic reticulum lipid raft-associated protein 2 (ERLIN2) in glioblastoma tissues, and to analyze its correlation with the clinicopathological features and prognosis of patients with glioblastoma.Methods:The TCGA database was used to analyze the expression level of ERLIN2 mRNA in glioblastoma. KM-plotter was used to analyze the correlation between ERLIN2 expression and prognosis in patients with glioblastoma. The expression level of ERLIN2 protein in 78 cases of glioblastoma tissue was determined by immunohistochemical staining, and then the tissue samples were divided into high expression and low expression groups according to the ERLIN2 expression level. The clinical and pathological data of patients were collected, including age, gender, tumor laterality, recurrence, isocitrate dehydrogenase(IDH) mutation, and the correlation between ERLIN2 protein and clinicopathological characteristics was further analyzed.Results:The mRNA of ERLIN2 was significantly overexpressed in glioblastoma, and the overall survival rate of patients with high ERLIN2 expression was low, suggesting a poor prognosis. The results of immunohistochemistry and clinicopathological analysis showed that ERLIN2 protein was significantly overexpressed in glioblastoma, and its expression level was significantly related to tumor recurrence.Conclusions:ERLIN2 protein is significantly overexpressed in glioblastoma tissues, and its expression level is related to the clinicopathological characteristics and poor prognosis, suggesting that ERLIN2 can be used as a potential prognostic factor for glioblastoma.
