Systematic evaluation of efficacy and safety of Huangqi Guizhi Wuwu Decoction for preventing oxaliplatin-induced peripheral neurotoxicity
10.3760/cma.j.issn.1673-4181.2020.01.004
- VernacularTitle:黄芪桂枝五物汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价
- Author:
Hui WANG
1
;
Xiaochen WEI
;
Liqin ZHU
;
Chunge WANG
;
Qi DENG
;
Xin LI
Author Information
1. 南开大学附属医院（天津市第四医院）药剂科 300222
- From:
International Journal of Biomedical Engineering
2020;43(1):24-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of Huangqi Guizhi Wuwu Decoction for preventing oxaliplatin-induced peripheral neurotoxicity(OIPN).Methods:PubMed, ScienceDirect, EMbase, VIP, CNKI and WanFang Data were searched to collect the randomized controlled trials(RCTs) of Huangqi Guizhi Wuwu Decoction for OIPN from the date of establishment until July 2019. Two reviewers independently evaluated the quality of literature and extracted data. RevMan5.3 software was used for Meta-analysis.Results:Fifteen RCTs (849 patients) were included. The results of Meta-analyses showed statistically significant differences in favor of Huangqi Guizhi Wuwu Decoction group compared with control group for all incidence of OIPN [ RR=0.57, 95% CI(0.40, 0.81), P=0.002] and incidence of serious OIPN [ RR=0.35, 95% CI(0.25, 0.48), P<0.000 01]. No differences were observed in disease control rates between two groups. There was statistically significant differences between Huangqi Guizhi Wuwu Decoction group and mecobalamine group for all incidence of OIPN [ RR=0.51, 95% CI(0.39, 0.66), P<0.000 01] and incidence of serious OIPN [ RR=0.37, 95% CI(0.19, 0.70), P=0.002]. Conclusions:Huangqi Guizhi Wuwu Decoction is more safety and effective than mecobalamine on the prevention of OIPN and did not affect the efficacy of chemotherapy. So Huangqi Guzhi Wuwu decoction can be widely extended to clinical applications.
