Triggering factors of acute ischemic stroke: a hospital-based cross-sectional observational study
10.3760/cma.j.issn.1673-4165.2020.09.002
- VernacularTitle:急性缺血性卒中的触发因素：基于医院的横断面观察性研究
- Author:
Qiuhong JIANG
1
;
Xinyi HUANG
;
Liming SHU
;
Su XIAO
;
Xiuhui CHEN
;
Hua HONG
Author Information
1. 中山大学附属第一医院神经科，广东省重大神经疾病诊治研究重点实验室，国家临床重点专科和国家重点学科，广州 510080；中山大学附属第七医院，深圳 518107
- From:
International Journal of Cerebrovascular Diseases
2020;28(9):647-654
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the triggering factors of ischemic stroke and their correlation with stroke severity and traditional risk factors.Methods:The clinical data of patients with ischemic stroke within 2 weeks of the onset were collected retrospectively. They were divided into two groups according to the questionnaire of triggering factors. The demographic and baseline data of the two groups were compared. According to the National Institutes of Health Stroke Scale (NIHSS) score, the patients were divided into low NIHSS score group (≤8) and high NIHSS score group (>8). The demographic and baseline data were compared. Multivariate logistic regression analysis was used to determine the independent related factors of the existence of triggering factors in patients with ischemic stroke and the correlation between the existence of triggering factors and the severity of stroke. Results:A total of 217 patients were enrolled in the study. Their age was 63.4±12.8 years and 148 were male (68.2%). One hundred and nine patients had at least one triggering factor. Common triggering factors were sleep disorders (46.8%), infection (18.4%), and missed medication (13.8%). Multivariate logistic regression analysis showed that after adjusting for confounding factors, diabetes mellitus (odds ratio [ OR]2.496, 95% confidence interval [ CI]1.347-4.626; P=0.047), large artery atherosclerosis ( vs. small vessel occlusion: OR 2.168, 95% CI 1.060-4.343; P=0.034) and baseline NIHSS score (the fourth quartile vs. the first quartile: OR 2.320, 95% CI 1.043-5.162; P=0.039) were independently associated with the existence of triggering factors in patients with ischemic stroke, and any of the triggering factors was independently associated with stroke severity ( OR 2.042, 95% CI 1.106-3.770; P=0.023). Conclusion:Diabetes and the severity of stroke are associated with the existence of triggering factors in patients with ischemic stroke. Stroke severity in ischemic stroke patients with triggering factors is more severe.
