Pathophysiological mechanism of white matter hyperintensities
10.3760/cma.j.issn.1673-4165.2020.08.010
- VernacularTitle:脑白质高信号的病理生理学机制
- Author:
Hui MA
1
;
Luqing ZHAO
;
Juan ZHANG
Author Information
1. 山西医科大学附属人民医院神经内科，太原 030012
- From:
International Journal of Cerebrovascular Diseases
2020;28(8):620-624
- CountryChina
- Language:Chinese
-
Abstract:
White matter hyperintensities (WMHs) are one of the MRI markers of cerebral small vessel disease, which are more common in the elderly, and are closely associated with the clinical manifestations such as cognitive impairment and gait disorder, however, the pathophysiological mechanism is currently unclear. This article expounds the possible pathophysiological mechanisms of WMHs from many aspects, such as hypoperfusion, blood-brain barrier destruction, oxidative stress, inflammation, and genetics.
