Migraine and risk of hemorrhagic stroke: a meta-analysis
10.3760/cma.j.issn.1673-4165.2020.07.008
- VernacularTitle:偏头痛与出血性卒中发病风险的meta分析
- Author:
Jiacai ZUO
1
;
Qi YANG
;
Yufeng TANG
;
Jinfeng DUAN
;
Zhonglun CHEN
;
Xianrong ZENG
;
Mingjun PU
;
Yi YANG
;
Yun ZHANG
Author Information
1. 绵阳市中心医院神经内科 621000
- From:
International Journal of Cerebrovascular Diseases
2020;28(7):522-529
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To comprehensively evaluate the correlation between migraine and the risk of hemorrhagic stroke using Meta-analysis.Methods:The published observational studies on migraine and the risk of hemorrhagic stroke in PubMed, EMbase, Cochrane library, Chinese Biomedical Database, China Journal Full-text Database, Wanfang Database and VIP Database were retrieved by computers. The retrieval time limit was from the establishment of the databases to December 31, 2019. Two reviewers independently conducted the literature screening and data extraction, and evaluated the quality according to Newcastle Ottawa scale. Stata SE 12.1 software was used for Meta-analysis.Results:Six case-control studies and 7 cohort studies met the inclusion criteria, all of which were in English. The results of Meta-analysis showed that exposure to migraine increased the risk of hemorrhagic stroke (odds ratio [ OR] 1.47, 95% confidence interval [ CI] 1.23-1.76; P<0.001). Sensitivity analysis showed that the results were robust. Subgroup analysis showed that migraine with aura ( OR 1.38, 95% CI 1.05-1.81; P=0.019), migraine without aura ( OR 1.46, 95% CI 1.19-1.80; P<0.001), male ( OR 2.10, 95% CI 1.72-2.56; P<0.001) and female ( OR 1.53, 95% CI 1.22-1.92; P<0.001) migraine could increase the risk of hemorrhagic stroke. Conclusion:Regardless of the gender of patients and presence or absence of migraine aura, migraine can significantly increase the risk of hemorrhagic stroke.
