Roles of gap junction proteins and pannexins in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2020.06.013
- VernacularTitle:缝隙连接蛋白和泛连接蛋白在脑缺血中的作用
- Author:
Xinyue WANG
1
;
Yingzhu CHEN
;
Hailong YU
;
Li JIANG
Author Information
1. 大连医科大学 116044
- From:
International Journal of Cerebrovascular Diseases
2020;28(6):472-476
- CountryChina
- Language:Chinese
-
Abstract:
There are a wide range of gap junction proteins and pannexins between brain cells. The neurovascular unit, which are composed of neurons, glial cells and vascular cells, integrate and process information through cell membrane channels composed of gap junction proteins and pannexins, so as to maintain the dynamic balance of the nervous system. After cerebral ischemia, cell membrane channels play an important role in ischemic brain injury by participating in excitatory toxicity, inflammatory response, blood-brain barrier injury and other pathological mechanisms. Therefore, maintaining the normal function of gap junction proteins and pannnexins is essential to protect neurons from ischemic brain injury.
