Anti-inflammatory effects of lipoxin A4 in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2020.05.014
- VernacularTitle:脂氧素A4在脑缺血中的抗炎作用
- Author:
Bo YANG
1
;
Jianhong WANG
;
Nengwei YU
Author Information
1. 西南医科大学临床医学院，泸州 646000；四川省医学科学院 四川省人民医院神经内科，成都 610072
- From:
International Journal of Cerebrovascular Diseases
2020;28(5):391-396
- CountryChina
- Language:Chinese
-
Abstract:
Lipoxin A4 (LXA4) is one of the metabolites of arachidonic acid, and it is an endogenous anti-inflammatory factor that can alleviate the inflammatory reaction through various pathways. Inflammatory response plays an important role in the process of cerebral ischemia. LXA4 can play a protective role on nerve cells by regulating proinflammatory cytokines, protecting blood-brain barrier, inhibiting activation and infiltration of leukocyte, alleviating local microcirculation inflammatory response, regulating inflammatory mediators such as leukotrienes and inflammasome, regulating the metabolism of inflammatory related enzymes, and alleviating oxidative stress injury. This article reviews the anti-inflammatory effects of LXA4 in cerebral ischemia.
