Circadian clock and ischemic stroke
10.3760/cma.j.issn.1673-4165.2020.04.010
- VernacularTitle:生物钟与缺血性卒中
- Author:
Jing JIN
1
;
Yumeng LIU
;
Jian GE
;
Dong ZHANG
;
Siyuan CHEN
;
Mingli HE
Author Information
1. 徐州医科大学附属连云港医院神经内科，连云港 222002
- From:
International Journal of Cerebrovascular Diseases
2020;28(4):293-297
- CountryChina
- Language:Chinese
-
Abstract:
Almost all life on Earth has a 24 h circadian rhythm. The circadian clock that controls the circadian rhythm is an important regulator of physiology and disease. Disturbance of circadian rhythm can negatively affect physiological homeostasis at the molecular, cellular, organ system, and whole organism levels. The circadian clock rhythm disorders are considered to be involved inmany cardiocerebrovascular diseases, such as ischemic stroke and myocardial infarction. Ischemic stroke is one of the main causes of long-term disability and death worldwide. The incidence is higher in the daytime and lower at night, but the exact mechanism of this time distribution is unclear. This article discusses the role of the circadian clock in stroke pathophysiological mechanism and the specific molecular mechanism of clock gene regulation. It is expected that molecular time can be used or changed to open up new targets for stroke treatment.
