Advances in the effect and mechanism of Faecalibacterium prausnitzii on immune regulation of inflammatory bowel disease
10.3760/cma.j.issn.1673-4408.2020.11.003
- VernacularTitle:普拉梭菌对炎症性肠病免疫调节的作用和机制研究进展
- Author:
Fang DONG
1
;
Fangfei XIAO
;
Yizhong WANG
;
Ting ZHANG
Author Information
1. 上海交通大学附属儿童医院 上海市儿童医院消化感染科 200062
- From:
International Journal of Pediatrics
2020;47(11):759-763
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease is a common digestive tract disease, and its incidence rate is increasing year by year.Changes of intestinal microecology in patients with inflammatory bowel disease are mainly manifested by the decreased species richness of intestinal microorganisms, among which the significant reduction of Faecalibacterium prausnitzii is one of its important characteristics.In addition, Faecalibacterium prausnitzii participates in the immune regulation of inflammatory bowel disease and plays an important role in the occurrence and development of inflammatory bowel disease.In this article, we reviewed the role and mechanism of Faecalibacterium prausnitzii involved in the immune regulation of inflammatory bowel disease by inhibiting inflammatory pathways, regulating the differentiation and function of Treg cells, and repairing intestinal mucosal barrier.By summarizing the specific mechanisms and roles of Faecalibacterium prausnitzii in the intestine, we hope to provide a basis for clinical treatment and research of inflammatory bowel disease.
