Prevention of folate deficiency with 5-methyl-tetrahydrofolate
10.3760/cma.j.issn.1673-4408.2020.10.011
- VernacularTitle:5-甲基四氢叶酸预防叶酸缺乏研究进展
- Author:
Shuowen WANG
1
;
Qizong ZHANG
;
Ting ZHANG
;
Li WANG
Author Information
1. 首都儿科研究所儿童发育营养组学北京市重点实验室 100020
- From:
International Journal of Pediatrics
2020;47(10):723-726
- CountryChina
- Language:Chinese
-
Abstract:
Folate is a water-soluble vitamin that cannot be synthesized by the body itself and must be obtained by external supplementation.There is substantial evidence that folate deficiency causes neural tube defects, partial birth defects, dementia, and certain types of cancer.However, excessive supplementation of folic acid(FA), the main form of supplementation at present, will increase the potential risk of certain diseases for oneself and future generations.Therefore, it is of great significance to explore new supplementation methods for folate supplementation in the population.This paper will discuss the progress of 5-methyltetrahydrofolate(5-MTHF)supplementation and the feasibility of replacing the chemical folic acid in terms of toxicology, bioavailability, vitamin B12 coverup, single nucleotide polymorphisms of folate metabolism-related enzyme genes, and fortification effect.
