Progress on the relationship between peroxiredoxin 2 and fibrotic diseases
10.3760/cma.j.issn.1673-4408.2020.09.011
- VernacularTitle:过氧化物酶2与纤维化疾病关系的研究进展
- Author:
Siwen QIN
1
;
Hong JIANG
Author Information
1. 中国医科大学附属第一医院儿科，沈阳 110001
- From:
International Journal of Pediatrics
2020;47(9):644-647
- CountryChina
- Language:Chinese
-
Abstract:
Organ fibrosis has always been a research hot topic in the medicine.The relationship between oxidative stress and fibrotic diseases is close.Peroxiredoxin 2(Prx2), an important antioxidant enzyme, exits in the body.Its outstanding antioxidant function can play an important role in the occurrence and development of fibrotic diseases.In addition, Prx2 is very sensitive to active reactive oxygen species levels.This feature has great research value in the diagnosis and prediction of fibrotic diseases.At the same time, Prx2 can affect apoptosis, regulate cell signal transduction and molecular chaperones.This article reviews the main functions of Prx2 and its effect on the lung, kidney, and liver fibrosis.Finally, it discusses the future hot topic and development trends of Prx2.
