Progress in the pathogenesis of Henoch-Sch?nlein purpura nephritis and IgA nephropathy in children
10.3760/cma.j.issn.1673-4408.2020.08.013
- VernacularTitle:儿童紫癜性肾炎与IgA肾病的发病机制研究进展
- Author:
Yingying TIAN
1
;
Xiaoshan SHAO
Author Information
1. 贵州医科大学，贵阳 550004
- From:
International Journal of Pediatrics
2020;47(8):569-572
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-Sch?nlein purpura nephritis and IgA nephropathy are both characterized by extensive deposition of IgA in the mesangial area.In recent years, the researches on the pathogenesis of the two diseases have made significant progress.It was confirmed that the pathogenesis included the aberrantly glycosylated IgA1, abnormal complement activation, cellular immune imbalance and cytokine production disorder, genetic factors and so on.Furthmore, some other immunopathogenic mechanisms have a breakthrough on endothelial cell particles, extracellular trapping nets, podocyte autophagy and abnormal peptide lineage, offering new ideas for diagnosis and treatment of disease.This paper will review the above pathogenesis.
