The Effect of Spinal Cord Injury on Pituitary-Testicular Hormone Axis in Rats.
- Author:
Yang Il PARK
1
;
Joon Hwa NOH
;
Bong Ryoul OH
;
Myung Sik YOO
Author Information
1. Department of Urology, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Spermatogenesis;
Spinal cord injury;
Pituitary-testicular hormonal axis
- MeSH:
Animals;
Axis, Cervical Vertebra*;
Humans;
Male;
Radioimmunoassay;
Rats*;
Rats, Sprague-Dawley;
Spermatogenesis;
Spinal Cord Injuries*;
Spinal Cord*;
Testis;
Testosterone
- From:Korean Journal of Urology
1998;39(10):947-951
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the effect of spinal cord injury(SCI) on male reproductive function, we evaluated changes of pituitary-testicular hormonal level at various time intervals in spinal cord injured rats. MATERIALS AND METHODS: SCI was produced in 30 sexually mature Sprague-Dawley rats by T10 spinal cord transection. 20 controls received similar surgery without transection. Testosterone concentrations in the serum and testis, serum levels of follicle-stimulating hormone(FSH) and leutenizing hormone(LH) were measured with radioimmunoassay. Two way analysis of variance(ANOVA) was performed. RESULTS: Testosterone levels in the serum and testis were lower at 2 weeks after injury than in controls, but others were not. Serum levels of FSH and LH were similar in both group. CONCLUSIONS: Spinal cord injury in rats induced impairment of testosterone production in testis at 2 weeks.
