Pathogenesis and treatment of the syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis
10.3760/cma.j.issn.1673-4408.2020.07.011
- VernacularTitle:周期性发热-阿弗他口炎-咽炎-淋巴结炎综合征发病机制及治疗进展
- Author:
Yuting PAN
1
;
Haiguo YU
Author Information
1. 南京医科大学附属儿童医院风湿免疫科 210008
- From:
International Journal of Pediatrics
2020;47(7):485-488
- CountryChina
- Language:Chinese
-
Abstract:
The syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA)is the most common cause of periodic fever in childhood.The diagnosis of PFAPA is typically made on clinical grounds.The patients usually show normal growth and development.The current pharmacological treatment includes corticosteroids for the management of febrile episodes, colchicine for the prophylaxis of febrile episodes, and other medication with unproven efficacy.Tonsillectomy is an option for selected patients.Usually PFAPA syndrome resolves during adolescence, but there is increasing evidence that this condition may persist into adulthood.This article reviews the pathogenesis and treatment of PFAPA in order to raise pediatricians′ awareness of this disease.
