Advances in lung epithelial stem cells
10.3760/cma.j.issn.1673-4408.2020.04.005
- VernacularTitle:肺上皮干细胞研究进展
- Author:
Jinglong CHEN
1
;
Aizhen LU
Author Information
1. 复旦大学附属儿科医院呼吸科，上海 201102
- From:
International Journal of Pediatrics
2020;47(4):239-243
- CountryChina
- Language:Chinese
-
Abstract:
An in-depth understanding of the relevant cell types and mechanisms of lung regeneration has an important positive effect on the prevention and treatment of lung diseases.This review summarizes the recent advances in the classification, characteristics, and mechanisms of self-renewal and differentiation of lung epithelial stem cells.Lung epithelial stem cells include basal cells, club cells, pulmonary neuroendocrine cells, bronchioloalveolar stem cells, distal airway stem cells and alveolar epithelial stem cells.Mechanisms include Wnt, notch, innate immune signaling pathways and others related to growth factors and transcription factors.
