Progress of Wnt/β-catenin signaling pathway in the remodeling of asthma airway
10.3760/cma.j.issn.1673-4408.2020.03.003
- VernacularTitle:Wnt/β-catenin信号通路与哮喘气道重塑的研究进展
- Author:
Hanping WU
1
;
Man TIAN
Author Information
1. 南京医科大学附属儿童医院呼吸科 210008
- From:
International Journal of Pediatrics
2020;47(3):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic airway inflammatory disease, and airway remodeling is one of its typical pathological features.Airway remodeling can result in hyperactivity, irreversible airflow limitation, and even decreased lung function.Studies have shown that the Wnt/β-catenin signaling pathway plays an important role in post-injury repair of the lung.Abnormal activation of the Wnt/β-catenin signaling pathway leads to airway remodeling in asthma.This article will review the progress of Wnt/β-catenin signaling pathway and asthma-related airway remodeling, and explore its possible therapeutic targets in asthma.
