Progress of the relationship between cytokines and lymphoma
10.3760/cma.j.cn115356-20190827-00164
- VernacularTitle:细胞因子与淋巴瘤关系的研究进展
- Author:
Guoli SONG
1
;
Yajie WANG
;
Zengzheng LI
;
Renfang LI
;
Tonghua YANG
Author Information
1. 昆明医科大学研究生院 650000
- From:
Journal of Leukemia & Lymphoma
2020;29(9):566-569
- CountryChina
- Language:Chinese
-
Abstract:
At present, the treatment methods of lymphoma mainly include the combined chemotherapy, hematopoietic stem cell transplantation, immunotherapy and new targeted therapies, but the treatment-related drug resistance, recurrence, extranodal and central nervous system infiltration, and leukemia transformation are still intractable problems that need to be solved in clinical practice. Studies have shown that cytokines are expressed to varying degrees in patients with lymphoma, which are significantly related to the progression of lymphoma, poor prognosis, chemotherapy response, and drug resistance. It has been confirmed that interleukin 6 (IL-6) and IL-10 are highly expressed in all types of lymphoma, and IL-10 is highly expressed in the cerebrospinal fluid of central nervous system lymphoma, all of which indicate a poor prognosis. This article reviews the role of cytokines in the development, treatment and prognosis of lymphoma.
