Pharmacogenetics progress of commonly-used chemotherapeutic drugs for acute leukemia

VernacularTitle:急性白血病患者常用化疗药物的遗传药理学研究进展
Author: Hanbing YAN ¹ ; Yanan ZHANG ; Min LIN ; Yan JIANG ; Wei LIANG ; Hui HE
Author Information

1. 辽宁省本溪市中心医院科研实验室　117000
From: Journal of Leukemia & Lymphoma 2020;29(5):317-320
CountryChina
Language:Chinese
Abstract: Leukemia is a common and harmful disease for humans. Chemotherapy is the main treatment method. During the decades of experience, the clinicians have found that these drugs work well, but obvious individual differences occur in different patients. Some concerns of the clinicians exist such as how to learn more about the factors that may induce drug resistance and adverse reactions, and how to improve the efficacy of chemotherapy drugs, reduce drug resistance and side effects. This paper reviews the effect of genetic factors of commonly-used chemotherapeutic drugs for acute leukemia, aiming to provide a theoretical foundation for personalized administration of these chemotherapeutic drugs.