Acute myeloid leukemia with BCR-ABL p210 fusion gene-positive: report of one case and review of literature

VernacularTitle:BCR-ABL p210融合基因阳性急性髓系白血病一例并文献复习
Author: Ju HUANG ¹ ; Yanxia HAN ; Fangxian WEI ; Shanhua SHEN ; Beili HU ; Lihua CHEN ; Zhouzheng WANG
Author Information

1. 浙江省嘉兴学院附属第二医院　嘉兴市第二医院血液内科　314000
From: Journal of Leukemia & Lymphoma 2020;29(3):175-178
CountryChina
Language:Chinese
Abstract: Objective:To investigate the clinical characteristics of acute myeloid leukemia with BCR-ABL p210 fusion gene-positive.Methods:The clinical characteristics of a patient diagnosed in the Second Hospital of Jiaxing were analyzed and the related literature was reviewed.Results:BCR-ABL p210 fusion gene and Philadelphia chromosome (Ph) were detected by reverse transcription-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH). Imatinib associated with multi-drug intravenous chemotherapy resulted in poor efficacy.Conclusions:Patient with Ph +/BCR-ABL + acute myeloid leukemia is rare with a very poor prognosis. There is no unified standard treatment and the efficacy of tyrosine kinase inhibitors is unclear. Intravenous chemotherapy combined with hematopoietic stem cell transplantation is expected to change the prognosis.