Multi-disciplinary team on renal allograft dysfunction induced by recurrence of primary hyperoxaluria type I after renal transplantation
10.3969/j.issn.1674-7445.2021.01.012
- VernacularTitle:肾移植术后Ⅰ型原发性高草酸尿症复发致移植肾功能不全的多学科综合诊疗
- Author:
Yuchen WANG
1
;
Ziyan YAN
;
Wenfeng DENG
;
Renfei XIA
;
Wenli ZENG
;
Jia LUO
;
Jian XU
;
Yun MIAO
Author Information
1. Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China
- Publication Type:Research Article
- Keywords:
Renal transplantation;
Primary hyperoxaluria (PH);
Multi-disciplinary team (MDT);
End stage renal disease;
Renal allograft dysfunction;
Alanine glyoxylate aminotransferase (AGT);
Gene mutation;
Genetic screening
- From:
Organ Transplantation
2021;12(1):77-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and the experience of multi-disciplinary team (MDT) on recurrence of primary hyperoxaluria (PH) type I after renal transplantation. Methods One case presenting with unexplained rapid decline of renal allograft function after allogeneic renal transplantation was discussed by MDT. The role of MDT in diagnosing rare hereditary diseases and improving the long-term survival of renal transplant recipients was summarized. Results After MDT consultation, the patient was diagnosed with recurrence of PH type I. Routine immunosuppressive regimen was initiated after the exclusion of rejection. The patient was instructed to drink a large quantity of water, and given with high-quality protein and low-phosphorus diet, vitamin B6, calcium and other conservative therapies to actively prevent and treat postoperative complications. The deterioration of renal graft function was delayed. Nevertheless, regular hemodialysis was resumed at 5 months after renal transplantation until the submission date of this manuscript. Conclusions Recurrence of PH type I after renal transplantation is relatively rare. The main clinical manifestations are recurrent kidney stones and decreased renal function with multiple complications and poor prognosis. The condition of the patient is consulted by MDT for confirming the diagnosis, determining the optimal treatment scheme, delaying the progression and improving the clinical prognosis.
