Meta-Analysis for Effect of Danhong Injection on Cardiac Function and TIMI During Perioperative PCI in Acute Myocardial Infarction
10.13422/j.cnki.syfjx.20200144
- VernacularTitle:丹红注射液对急性心肌梗死PCI围手术期心功能和TIMI血流影响的Meta分析
- Author:
Meng-chen YUAN
1
;
Yong-hong GAO
1
;
Jie WANG
2
;
Bu-chang ZHAO
3
;
Yan-wei XING
2
;
Jun LI
2
;
Heng-wen CHEN
2
;
Tao ZHAO
3
;
Chao ZHAO
3
;
Yi-min WANG
3
Author Information
1. Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
2. Guang' anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China
3. Buchang Pharmaceuticals Co. Ltd., Xi' an 712000, China
- Publication Type:Research Article
- Keywords:
acute myocardial infarction (AMI);
percutaneous coronary intervention (PCI);
Meta-analysis;
left ventricular ejection fraction (LVEF);
brain natriuretic peptide (BNP);
thrombolysis in myocardial infarction (TIMI);
cardiac function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(1):178-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective::Evaluate the effects of Danhong injection for perioperative percutaneous coronary intervention (PCI) on cardiac function and thrombolysis in myocardial infarction (TIMI) in patients with acute myocardial infarction (AMI). Method::Computer retrieving CNKI, Wanfang database, VIP database, PubMed, CBM, Web of Science, The Cochrane Library, gathering Danhong injection in percutaneous coronary intervention perioperative application in the treatment of acute myocardial infarction clinic trials. The Cochrane risk evaluation is adopted to improve the quality of literature evaluation, with Revman 5.3 software for Meta-analysis. Result::Participants included in 12 clinic trials contains a total of 1 131 patients, including 569 patients in Danhong treatment and 562 patients in control group. The results showed that compared with conventional treatment, Danhong injection treated patients had LVEF increased obviously [mean difference (MD)=6.62, 95% confidence interval (CI) (4.91, 8.34), P<0.000 01], the number of TIMI class 3 patients significantly increased[relative risk (RR)=0.22, 95%CI(0.12, 0.41), P<0.000 01], and BNP levels significantly decreased [MD=151.86, 95%CI (-247.00, -56.72), P=0.002]. Conclusion::Danhong injection can improve the function of acute myocardial infarction after percutaneous coronary intervention.
