Clinical Efficacy of Flavored Sanxitang Combined with Celecoxib in Treatment of Gonarthromeningitis Cased by Dampness and Cold
10.13422/j.cnki.syfjx.20200521
- VernacularTitle:加味散膝汤联合塞来昔布治疗膝关节滑膜炎寒湿痹阻证的疗效观察
- Author:
Rui-ting ZUO
1
;
Qing-liang MENG
1
;
Jun-fu MA
1
;
Hui-min GU
1
Author Information
1. Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China
- Publication Type:Research Article
- Keywords:
flavored Sanxitang;
celecoxib;
dampness and cold syndrome;
gonarthromeningitis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2020;26(7):98-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective::To observe the clinical efficacy of flavored Sanxitang combined with celecoxib in treating gonarthromeningitis caused by dampness and cold. Method::Totally 120 case were randomly divided into the control group and the treatment group, with 60 cases in each group. The control group was given celecoxib, and the treatment group was treated with flavored sanxitang combined with celecoxib for 30 d. The visual analogue scale (VAS), American knee association knee function scale (AKS), arthritis impact scale (AIMS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were observed before and after treatment. The circumferential diameter, articular cavity effusion and synovial hyperplasia thickness were measured. The serum tumor necrosis factor-α(TNF-α), matrix metalloproteinase (MMP)-3, serum interleukin-1 (IL-1) and erythrocyte sedimentation rate (ESR) were detected. The effective rate and adverse reactions were observed in two groups. Result::The total effective rate in treatment group was 94.8% (55/58), which was higher than 80.7% (46/57) in control group (P<0.05). Compared with before treatment, VAS, AIMS, WOMAC, knee circumference, articular cavity effusion and synovial hyperplasia thickness were significantly reduced in two groups (P<0.05), while the AKS score was significantly increased (P<0.05). Compared with after treatment, VAS, AIMS, WOMAC, knee circumference, articular cavity effusion and synovial hyperplasia thickness were significantly reduced in observation group (P<0.05), whereas the AKS score was significantly increased (P<0.05). TNF-α, MMP-3, IL-1 and ESR in two groups were significantly lower than those group before treatment (P<0.05). After treatment, TNF-α, MMP-3, IL-1 and ESR levels in observation group were significantly reduced compared with those in control group (P<0.05). The incidence rate of adverse reactions in treatment group was 5.89% (4/58), which was lower than 22.81% (13/57) in control group (P<0.05). Conclusion::Flavored Sanxitang combined with celecoxib could alleviate the clinical symptoms of gonarthromeningitis caused by dampness and cold, with a low incidence of adverse reactions.
