Literature Analysis for Network Pharmacology Research of TCM Compound Prescription
- VernacularTitle:中药复方网络药理学研究的文献分析
- Author:
Xiuyun LI
1
;
Xinyou ZHANG
1
;
Diyao WU
2
;
Shumao PAN
1
;
Liang DING
3
;
Mengling LIU
3
Author Information
1. School of Pharmacy，Jiangxi University of TCM，Nanchang 330004，China
2. Evidence-based Medicine Center，Jiangxi University of TCM，Nanchang 330004，China
3. School of Computing，Jiangxi University of TCM，Nanchang 330004，China
- Publication Type:Journal Article
- Keywords:
TCM compound prescription;
Network ph armacology;
Database;
Research field;
Application;
Literature analysi s
- From:
China Pharmacy
2021;32(2):182-189
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To comprehensi vely evaluate the application progress of network pharmacology methods in TCM compound prescription research ，and to provide reference for modernization of TCM compound prescription research. METHODS ： Taking“network pharmacology ”and“TCM compound prescription ”as keywords ，the literatures were retrieved from CNKI ， Wanfang database and VIP during May 2006 to May 2020. Screening literature ，the databases ，analysis platforms ，and software used of the literature were summarized ；on the basis of quantitative analysis ，the application of network pharmacology in the research of traditional Chinese medicine compound were summarized. RESULTS & CONCLUSIONS ：There were a total of 761 valid literatures ，among which the number of literatures that could be retrieved in 2019 reached 313. In the modernization research of TCM compound prescription ，network pharmacology methods were mainly usedmechanism ，material basis of pharmacodynamics ， compatibility law ，compound optimization ，and“effect-toxic”network. Commonly used databasesand platforms included traditional chinese medicine information database （TCMSP and TCMID ），therapeutic target database （TTD，OMIM），drug targets and target prediction platform （Drugbank，SwissTargetPrediction，TargetNet，PharmMapper），network pharmacology analysis and prediction software and platform （CytoScape），etc. Network pharmacology method was widely used in the field of TCM compound prescription research ，and provided new ideas and methods for the modernization of TCM compound prescription research. In the future，the related research can be combined with the pharmacokinetic parameters ，the efficacy of active compounds and related basic experiments ，use the weighted method to carry out network pharmacology analysis ，and integrate the information of multiple databases to improve the scientificity of research results.
