Case-control study of early liferelated risk factors associated with type 1 diabetes mellitus in children
10.16835/j.cnki.1000-9817.2021.01.031
- VernacularTitle:儿童1型糖尿病生命早期相关影响因素的病例对照研究
- Author:
LIU Hezuo, SUN Qi, WEI Wei, ZHAI Lingling, BAI Yinglong, JIA Lihong
1
Author Information
1. Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang(110122),China
- Publication Type:期刊文章
- Keywords:
Diabetes mellitus,tpye 1;
Case-control studies;
Regression analysis;
Child
- From:
Chinese Journal of School Health
2021;42(1):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the affecting factors of type 1 diabetes mellitus(T1DM) in children, and to provide reference for the prevention and treatment measures in the future.
Methods:A case-control study was carried out among 106 children diagnosed with T1DM in a hospital in Shenyang. At the same time, 106 healthy children were selected as the control group by 1∶1 matching of age, gender and living area. The early life-related factors that may affect the development of T1DM in two groups were investigated by questionnaire.
Results:The average age of diagnosis in 106 cases with T1DM was(8.02±3.49) years, girls accounted for 60.4% and boys 39.6%. Multi-factor Logistic regression analysis showed that high family socioeconomic status and higher education of fathers were associated with lower odds of development of T1DM. Family member smoking(OR=2.51, 95%CI=1.19-5.29), family history of diabetes(OR=2.56, 95%CI=1.18-5.55), maternal obesity(OR=5.42, 95%CI=2.49-11.83) and infection during pregnancy(OR=3.45, 95%CI=1.04-11.46) were associated with higher risk of T1DM(P<0.05).
Conclusion:The occurrence of T1DM in children is affected by many factors including heredity, maternal health during pregnancy and family economy,highlighting the importance of early life prevention of T1DM.
