Current trends of Hepatitis C virus genotypes and associated risk factors in hemophilia patients in Pakistan
https://doi.org/10.47665/tb.37.4.1000
- Author:
Yaqoob, M.
1
;
Khan, S.
1
;
Atta, S.
2
;
Khan, S.N.
3
Author Information
1. Department of Zoology, University of Peshawar Khyber Pakhtunkwa Pakistan
2. Department of Zoology, Islamia College Peshawar Khyber Pakhtunkwa Pakistan
3. Department of Zoology, Kohat University of Science and Technology Kohat Khyber Pakhtunkwa Pakistan
- Publication Type:Journal Article
- From:Tropical Biomedicine
2020;37(No.4):1000-1007
- CountryMalaysia
- Language:English
-
Abstract:
Hemophilia is a rare bleeding disorder that needs plasma or clotting factor
concentrate transfusion. Therefore chances of blood-borne pathogens like HCV transmission
increase due to high prevalence in healthy donors. This study was aimed to determine the
prevalence of HCV genotypes and associated risk factors in hemophilia patients of Khyber
Pakhtunkhwa, Pakistan. Blood samples and data were collected from 672 hemophiliacs after
proper consent obtained from each patient. Samples were analyzed for anti-HCV, HCV RNA
and HCV genotype/s detection. Of the total, 22.32% (150) were anti-HCV positive, of which
HCV RNA was detected in 18.45% (124) individuals. HCV genotype 3a was found with
significantly higher prevalence (p<0.05) (19.35%) as compared to 2a (16.13%) and 1a (12.90%).
HCV-3b and HCV-4 were found each in 3.22% samples. Dual infection of genotypes was found
in 22.58% of individuals and 22.58% HCV RNA positive sampels were not typed. A total of 572
(85.12%) subjects had hemophilia A and 100 (14.88%) had hemophilia B. In hemophiliacs A the
most dominant genotype was 3a (19.27%) while in hemophilia B, genotype 1a was prevalent
(26.67%). Whole blood and plasma transfusion were observed as the main risk factors of HCV.
It is concluded that HCV genotype 3a and 2a are prevalent in hemophilia patients of Khyber
Pakhtunkhwa Pakistan and the main risk factor observed was an unscreened whole blood
transfusion.
- Full text:8.2020my1184.pdf
