Research advances in animal models of acute liver failure
DOI:10.3969/j.issn.1001-5256.2021.01.045
- VernacularTitle:急性肝衰竭动物模型的研究进展
- Author:
Fuli LONG
1
;
Yong LIN
;
Ziming PENG
;
Feng FENG
;
Jianling ZHANG
;
Dewen MAO
;
Ailing WEI
Author Information
1. Graduate School, Guangxi University of Chinese Medicine, Nanning 530200, China
- Publication Type:Research Article
- Keywords:
Liver Failure, Acute;
Disease Models, Animal;
Modeling Method
- From:
Journal of Clinical Hepatology
2021;37(1):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Acute liver failure is a serious and complex liver disease with a high short-term mortality rate. Its pathogenesis remains unknown and there is still a lack of effective drugs. Animal models play an important role in further revealing the pathogenesis of acute liver failure and the therapeutic mechanism of drugs, and the selection of experimental animals and preparation methods is the key to the effective implementation of research. This article summarizes the commonly used and new animal models of acute liver failure in recent years and the corresponding preparation methods and divides the animal models of acute liver failure into following four categories: chemical drug model, surgical model, infection model, and other models. Meanwhile, the above models are evaluated based on Terblanche and Hickman evaluation criteria for liver failure models, hoping to provide a reference for model selection and evaluation in basic research on this disease.
