Research advances in the association of the tyrosine kinase receptor Axl and its ligand Gas6 with hepatocellular carcinoma
DOI:10.3969/j.issn.1001-5256.2021.01.040
- VernacularTitle:受体酪氨酸激酶Axl及其配体Gas6与肝细胞癌的关系
- Author:
Yu WU
1
;
Ping’an QIAN
;
Xingliang FAN
;
Junfeng ZHU
Author Information
1. Department of Hepatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
Carcinoma, Hepatocellular;
Axl;
Growth Arrest Specific-6
- From:
Journal of Clinical Hepatology
2021;37(1):184-187
- CountryChina
- Language:Chinese
-
Abstract:
As one of the tyrosine kinase receptors, Axl is an important downstream regulator of epithelial-mesenchymal transition (EMT) and can bind to its ligand Gas6 protein. By activating the downstream signal transduction pathways, Axl is closely associated with vascular invasion, tumor metastasis, recurrence, and low survival rate of hepatocellular carcinoma. Current studies on the Gas6/Axl signaling pathway have confirmed that Axl inhibitors play an important role in the treatment of liver cancer and the Gas6/Axl signaling pathway may be a potential therapeutic target for liver cancer. This article mainly introduces the association of Axl and its ligand Gas6 with the development and progression of liver cancer and their application in the diagnosis and treatment of liver cancer, in order to provide new ideas for the early diagnosis of liver cancer and clinical research on anti-cancer treatment.
