Research advances in the regulation of epithelial-mesenchymal transition and targeted therapy for liver fibrosis
DOI:10.3969/j.issn.1001-5256.2021.01.035
- VernacularTitle:肝纤维化中上皮间质转化的调控及靶向治疗的研究进展
- Author:
Yongjuan WANG
1
;
Xiaoli XIE
;
Huiqing JIANG
Author Information
1. Department of Gastroenterology, The Second Hospital of Hebei Medical University
- Publication Type:Research Article
- Keywords:
Liver Cirrhosis;
Epithelial-Mesenchymal Transition;
Therapeutics
- From:
Journal of Clinical Hepatology
2021;37(1):165-168
- CountryChina
- Language:Chinese
-
Abstract:
The pathological basis of liver fibrosis is the deposition of extracellular matrix (ECM), and myofibroblasts are the main source of ECM. Epithelial-mesenchymal transition (EMT) is one of production mechanisms of myofibroblasts. At present, a large number of studies have shown that intervention of key EMT molecules and signaling pathways as targets can reduce liver fibrosis. Based on literature review, this article summarizes the signaling pathways associated with EMT, important regulatory molecules, and drugs targeting EMT in the treatment of liver fibrosis, so as to provide new ideas for the treatment of liver fibrosis.
