Research progress on microRNA-21 in regulating osteoclast and osteogenic differentiation in orthodontic treatment
10.12016/j.issn.2096-1456.2021.03.013
- Author:
CHEN Zece
1
;
LONG Qian
1
;
GUAN Xiaoyan
1
;
LIU Jianguo
2
,
3
Author Information
1. School of Stomatology, Zunyi Medical University
2. 1. School of Stomatology, Zunyi Medical University 2.The Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province &
3. the Key Laboratory of Oral Diseases Research of Zunyi City
- Publication Type:Review
- Keywords:
microRNAs;
microRNA-21;
orthodontic treatment;
orthodontic tooth movement;
osteogenic differentiation;
osteoclast differentiation;
bone modeling;
periodontal tissue
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(3):211-216
- CountryChina
- Language:Chinese
-
Abstract:
In the process of orthodontic treatment, the balance between the modeling of alveolar bone and the mechanical stress exerted by the appliance is key to the effective movement of orthodontic teeth. Alveolar bone modeling involves many regulatory factors, and microRNAs (miRNAs), as posttranscriptional regulatory factors, play an important role in the occurrence of bone modeling. As an important member of the miRNA family, miRNA-21 promotes the differentiation of periodontal ligament stem cells into osteoblasts and plays an important role in maintaining bone balance and preventing bone resorption as a regulator of osteoclast formation and a promoter of osteoclast differentiation. A literature review showed that miRNA-21 can regulate osteoclast function and promote bone resorption through programmed cell death 4 (PDCD4), phosphate and tension homology deleted on chromosome ten (PTEN), receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG). MiRNA-21 is highly sensitive to external mechanical stress in the process of orthodontic tooth movement. After orthodontic force is applied, miRNA-21 can promote osteoclast formation and accelerate orthodontic movement; through targeted regulation of periodontal ligament associated protein-1 (PLAP-1), it can regulate periodontal ligament remodeling in the late stage of tooth movement and improve the potential of tooth movement. In addition, miRNA-21 mediates orthodontic tooth movement (OTM) and alveolar bone remodeling in the periodontal inflammatory microenvironment. miRNA-21 can upregulate the expression of hypoxia-inducible factor-1α (HIF-1α) in periodontal ligament stem cells in a hypoxic environment. It can promote the expression of osteogenic markers, such as osteopontin (OPN), osteocalcin (OCN), alkaline phosphatase (ALP) and runt-related transcription factor 2 (Runx2), and promote osteogenic differentiation during orthodontic tooth movement.
- Full text:MicroRNA-21调控破骨和成骨分化作用在正畸治疗中的研究进展.pdf
