Research progress on the role of T helper cells 17 and interleukin 17 in oral mucosal diseases
10.12016/j.issn.2096-1456.2021.03.009
- Author:
WANG Ziying
1
;
CHEN Xiaotao
2
,
3
Author Information
1. Xinjiang Medical University School of Stomatology
2. Department of Stomatology, The People&prime
3. s Hospital of the Xinjiang Uygur Autonomous Region
- Publication Type:Review
- Keywords:
T helper cells 17;
interleukin 17;
oral mucosal disease;
oral lichen planus;
oral ulcer;
recurrent aphthous ulcer;
Behcet′s disease;
proinflammatory effect
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(3):194-197
- CountryChina
- Language:Chinese
-
Abstract:
T helper 17 (Th17) cells are a new type of CD4+ T helper cell. They participate in the immune and inflammatory response by secreting specific interleukin-17 (IL-17). In oral mucosal diseases, oral lichen planus (OLP), recurrent aphthous ulcer (RAU) and Behcet′s disease (BD) are associated with Th17 cells and IL-17. There were 17 kinds of proteins in the saliva of patients with OLP that could upregulate the expression of Th17 cells and induce the secretion of IL-17. IL-17 can stimulate epithelial cells, endothelial cells and fibroblasts to produce a variety of cytokines, such as IL-6, IL-8, granulocyte macrophage colony-stimulating factor and cell adhesion molecule-1, leading to the production and aggravation of inflammation. Th17/Tc17 cell-targeted therapy can significantly improve the clinical symptoms of OLP patients′ mucosa and skin. IL-17 can stimulate oral keratinocytes through the IL-17RA or IL-17RE receptor and produce proinflammatory effects in RAU. Th17 cells in the peripheral blood of BD patients are significantly increased, while Treg cells are significantly decreased.
- Full text:辅助性T细胞17与白细胞介素17在口腔黏膜疾病中的研究进展.pdf
