Study on the quality control improvement of Dilong Shenmai oral liquid
10.12206/j.issn.1006-0111.202003189
- VernacularTitle:地龙参麦口服液质量标准提高研究
- Author:
Dong LIU
1
;
Zhihui HUA
2
;
Zhe HAO
1
;
Jun QU
1
;
Lijun WANG
1
;
Mingchun LI
3
Author Information
1. Department of Pharmacy, No.988 Hospital of Joint Logistic Support Force of PLA, Zhengzhou 450042, China.
2. Department of Pharmacy, Zhengzhou People’s Hospital, Zhengzhou 450003, China.
3. Department of Pharmacy, No.971 Hospital of Navy of PLA, Qingdao 266071, China.
- Keywords:
Dilong shenmai oral liquid;
HPLC;
TLC;
schisandrin;
ethylparaben
- From:
Journal of Pharmaceutical Practice
2021;39(1):68-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the quality control of Dilong Shenmai oral liquid. Methods TLC was used for the qualitative identification of Astragali Radix, Ophiopogonis Radix and Schisandrae Chinensis Fructus in Dilong Shenmai oral liquid. HPLC was used to determine the contents of schisandrin and ethylparaben in the preparation. Wondasil C18 column (250 mm×4.6 mm, 5 μm) was used with acetonitrile-water as the mobile phase at the flow rate of 1.0 ml/min for gradient elution. The detection wavelength was set at 254 nm, and column temperature was 30 ℃. Results TLC spots were clear and well-separated without negative interference. The linear ranges of schisandrin and ethylparaben were 5.81−58.06 μg/ml (r=0.999 9) and 25.29−252.94 μg/ml (r=0.999 9). The average recoveries were 99.35% (RSD=1.02%) and 99.72% (RSD=0.76%). Conclusion This method is simple, quick and accurate. It can be used for effective quality control of Dilong Shenmai oral liquid.
